کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5736261 | 1613226 | 2017 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Research reportHigh-gamma oscillations in the motor cortex during visuo-motor coordination: A tACS interferential study Research reportHigh-gamma oscillations in the motor cortex during visuo-motor coordination: A tACS interferential study](/preview/png/5736261.png)
- High-frequency, imperceptible, electrical stimulation of the motor cortex affects visuo-motor coordination.
- 80Â Hz stimulation enhances performance just after sudden changes in tracking trajectory.
- Effects take place between 200 and 500Â ms after the onset of a new unexpected motor program.
- Response to tACS suggests a functional role for gamma activity in the motor cortex.
BackgroundWhile the role of beta (â¼20Â Hz), theta (â¼5Â Hz) and alpha (â¼10Â Hz) oscillations in the motor areas have been repeatedly associated with defined properties of motor performance, the investigation of gamma (â¼40-90Â Hz) oscillatory activity is a more recent and still not fully understood component of motor control physiology, despite its potential clinical relevance for motor disorders.Objective/hypothesisWe have implemented an online neuromodulation paradigm based on transcranial alternating current stimulation (tACS) of the dominant motor cortex during a visuo-motor coordination task. This approach would allow a better understanding of the role of gamma activity, as well as that of other oscillatory bands, and their chronometry throughout the task.MethodsWe tested the effects of 5Â Hz, 20Â Hz, 60Â Hz (mid-gamma) 80Â Hz (high-gamma) and sham tACS on the performance of a sample of right-handed healthy volunteers, during a custom-made unimanual tracking task addressing several randomly occurring components of visuo-motor coordination (i.e., constant velocity or acceleration pursuits, turns, loops).ResultsData showed a significant enhancement of motor performance during high-gamma stimulation - as well as a trending effect for mid-gamma - with the effect being prominent between 200 and 500Â ms after rapid changes in tracking trajectory. No other effects during acceleration or steady pursuit were found.ConclusionsOur findings posit a role for high-frequency motor cortex gamma oscillations during complex visuo-motor tasks involving the sudden rearrangement of motor plan/execution. Such a “prokinetic” effect of high-gamma stimulation might be worth to be tested in motor disorders, like Parkinson's disease, where the switching between different motor programs is impaired.
Journal: Brain Research Bulletin - Volume 131, May 2017, Pages 47-54