کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5737493 | 1614716 | 2017 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Long-term voluntary exercise prevents post-weaning social isolation-induced cognitive impairment in rats
ترجمه فارسی عنوان
ورزش داوطلبانه درازمدت از اختلالات شناختی ناشی از انزوای اجتماعی پس از جدایی در موش صحرایی جلوگیری می کند
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کلمات کلیدی
EPMNGFMWMBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز SiE - SIEAnxiety - اضطرابSocial isolation - انزوای اجتماعیelevated plus maze - بالا به همراه پیچ و خمELISA - تست الیزاEnzyme-linked immunosorbent assay - تست الیزاCognitive function - عملکرد شناختیnerve growth factor - فاکتور رشد عصبBrain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزOpen field - میدان بازexercise - ورزش
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
This study aimed to determine the effect of exercise on locomotion, anxiety-related behavior, learning, and memory in socially isolated post-weaning rats, as well as the correlation between exercise and the concentration of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the hippocampus. Rats were randomly assigned to three groups: the control group; the social isolation group; the social isolation plus exercise (SIE) group. Social isolation conditions, with or without exercise were maintained for 90Â d, and then multiple behavioral tests, including the open-field test, elevated plus maze test, and Morris water maze (MWM) test were administered. Following behavioral assessment, hippocampal tissue samples were obtained for measurement of BDNF and NGF. There wasn't a significant difference in locomotor activity between the groups (PÂ >Â 0.05). Anxiety scores were higher in the socially isolated group (PÂ <Â 0.05) than in the SIE group (PÂ <Â 0.05). According to the probe trial session of the MWM test results, exercise training improved platform crossings' number in the socially isolated rats (PÂ <Â 0.05). Exercise training ameliorated social isolation-induced reduction in hippocampal BDNF and NGF content (PÂ <Â 0.05). These findings suggest that exercise training improves cognitive functions via increasing hippocampal BDNF and NGF concentrations in socially isolated post-weaning rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 360, 30 September 2017, Pages 1-8
Journal: Neuroscience - Volume 360, 30 September 2017, Pages 1-8
نویسندگان
Nilsel Okudan, Muaz Belviranlı,