کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5737500 | 1614716 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
L-DOPA inhibits excitatory synaptic transmission in the rat nucleus tractus solitarius through release of dopamine
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کلمات کلیدی
mEPSCsminiature EPSCsl-Dopa methyl esterIEIeEPSCsPPRDNQXNTSEGTAADNHEPES4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid - 4- (2-hydroxyethyl) -1-piperazineethanesulfonic acid6,7-dinitroquinoxaline-2,3-dione - 6،7-dinitroquinoxaline-2،3-dioneEPSC - EPSCoRl-DOPA - L-DOPAethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid - اتیلن گلیکول بیس (β-آمینویل اتر) -N، N، N '، N'-tetraacetic اسیدExcitatory synaptic transmission - انتقال سیناپسی هیجان انگیزexcitatory postsynaptic current - جریان پستیینپتیک تحریک کنندهDopamine - دوپامینaortic depressor nerve - عصب افسردگی آئورتInter-event Interval - فاصله بین رویدادpaired-pulse ratio - نسبت پالس زوجnucleus tractus solitarius - هسته دستگاه انفرادی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The mode of action of L-DOPA on excitatory synaptic transmission in second-order neurons of the nucleus tractus solitarius (NTS) was studied using the rat brainstem slices. Superfusion of L-DOPA (10 μM) reduced the frequency of miniature excitatory postsynaptic currents (mEPSCs) without any effect on the amplitude. A low concentration (1 μM) was ineffective on the mEPSCs, and the highest concentration (100 μM) exerted a stronger inhibitory effect. L-DOPA (10 μM) decreased the amplitude of EPSCs (eEPSCs) evoked by electrical stimulation of the tractus solitarius and increased the paired-pulse ratio. The inhibitory effects of L-DOPA on mEPSCs and eEPSCs were similar to those of dopamine (100 μM). The effects of L-DOPA were blocked by a competitive antagonist, L-DOPA methyl ester (100 μM) and also by a D2 receptor antagonist, sulpiride (10 μM), while those of dopamine were blocked by the latter but not by the former. In reserpine (5 mg/kg, s.c.)-treated rats, the effects of L-DOPA on both mEPSCs and eEPSCs were completely abolished, but those of dopamine remained unchanged. The present results suggest a possibility that L-DOPA may induce the release of dopamine from the axon terminals in the NTS and the released dopamine suppresses the glutamatergic transmission through activation of the presynaptic D2 receptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 360, 30 September 2017, Pages 18-27
Journal: Neuroscience - Volume 360, 30 September 2017, Pages 18-27
نویسندگان
Y. Ohi, D. Kodama, A. Haji,