کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5737666 | 1614717 | 2017 | 50 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Region-specific impairments in parvalbumin interneurons in social isolation-reared mice
ترجمه فارسی عنوان
اختلالات خاص منطقه در مویرگ های پرولاوبومین در موش های جداسازی اجتماعی
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کلمات کلیدی
CA3ectorhinal cortexPRHS1BFDACWFACA1ECTPNNVulnerability - آسیب پذیریcornu ammonis area 1 - آمون طبقه بال 1Social isolation - انزوای اجتماعیCornu Ammonis area 3 - بال 3 طبقه آمونPerineuronal net - خالص Perineuronalperineuronal nets - شبکه های perineuronaldentate gyrus - شکنج دندانه دارinfralimbic cortex - قشر infralimbicprimary somatosensory cortex - قشر اسموتیسنسوری اولیهprimary motor cortex - قشر حرکتی اولیهdorsal anterior cingulate cortex - قشر قدامی پشتی پشتیperirhinal cortex - قشر پریحینالprelimbic cortex - قشر پیش از قاعدگیMouse - موشWisteria floribunda agglutinin - ویستریا فلوریبند آگلوتیینینParvalbumin - پاروالبومین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Many neuropsychiatric disorders show localized dysfunction in specific cortical regions. The mechanisms underlying such region-specific vulnerabilities are unknown. Post-mortem analyses have demonstrated a selective reduction in the expression of parvalbumin (PV) in GABAergic interneurons in the frontal rather than the sensory cortex of patients with neuropsychiatric disorders such as schizophrenia, autism spectrum disorders, and bipolar disorders. PV neurons are surrounded by perineuronal nets (PNNs), and are protected from oxidative stress. Previous studies have shown that the characteristics of PNNs are brain region-specific. Therefore, we hypothesized that PV neurons and PNNs may be targeted in region-specific lesions in the brain. Oxidative stress was induced in mice by rearing them in socially isolated conditions. We systemically examined the distribution of PV neurons and PNNs in the brains of these mice as well as a control group. Our results show that the regions frequently affected in neuropsychiatric disorders show significantly lower PV expression and a lower percentage of PV neurons surrounded by PNNs in the brains of socially isolated mice. These results indicate that PV neurons and PNNs exhibit region-specific vulnerabilities. Our findings may be useful for elucidating the mechanisms underlying region-specific disruption of the brain in neuropsychiatric disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 359, 17 September 2017, Pages 196-208
Journal: Neuroscience - Volume 359, 17 September 2017, Pages 196-208
نویسندگان
Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Motoi Okamoto, Yosuke Matsumoto, Takeshi Ishihara,