کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5737749 | 1614732 | 2017 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of low-voltage-activated calcium current and extracellular calcium in controlling the firing pattern of developing CA1 pyramidal neurons
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کلمات کلیدی
regular-spikingLinopirdineMIBEGTALVAaCSFCA1 pyramidal neuronsADPTTXISI - آی اس آیethylene glycol tetraacetic acid - اتیلن گلیکول تتراستیک اسیدγ-aminobutyric acid - اسید γ-آمینوبوتیریکBAPTA - بیایپیتیایtetrodotoxin - تترو دوتوکسین Time constant - ثابت زمانیTau - خود راDevelopment - رشدinterspike interval - فاصله interterspeedLin - لینartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیMibefradil - میببرادیلhigh-voltage-activated - ولتاژ بالا فعال شده استaction potential - پتانسیل عمل TEA - چایHVA - چهLow-voltage-activated - کم ولتاژ فعالGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The firing pattern of individual neurons is an important element for information processing and storing. During the first weeks of development, there is a transitional period during which CA1 pyramidal neurons display burst-spiking behavior in contrast to the adult regular-firing pattern. Spike after-depolarizations (ADPs) constitute a major factor underlying burst-spiking behavior. Using current-clamp recordings, we studied ADP waveforms and firing patterns in CA1 pyramidal neurons of Wistar rats from 9 to 19 postnatal days (P9-19). The percentage of burst-spiking neurons increased up to P16, in correlation with the emergence of an active component in the ADP. The application of low-voltage-activated (LVA) calcium channel blockers such as nickel or mibefradil suppressed the generation of the active ADP component and burst-spiking behavior. In agreement with the development of the ADP waveform and burst-spiking behavior, voltage-clamp experiments in dissociated pyramidal neurons showed an increase in the LVA calcium current in P16-19 vs P9-12. Finally, we found that a reduction of extracellular calcium levels decreases the percentage of burst-spiking cells due to a reduction in the active component of the ADP. We conclude that a major contribution of LVA calcium channels to ADP determines the bursting capability of CA1 pyramidal neurons during a transitional postnatal period in contrast to adulthood.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 344, 6 March 2017, Pages 89-101
Journal: Neuroscience - Volume 344, 6 March 2017, Pages 89-101
نویسندگان
Alberto Sánchez-Aguilera, José Luis Sánchez-Alonso, MarÃa Ángeles Vicente-Torres, Asunción Colino,