کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5737749 | 1614732 | 2017 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of low-voltage-activated calcium current and extracellular calcium in controlling the firing pattern of developing CA1 pyramidal neurons
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کلمات کلیدی
regular-spikingLinopirdineMIBEGTALVAaCSFCA1 pyramidal neuronsADPTTXISI - آی اس آیethylene glycol tetraacetic acid - اتیلن گلیکول تتراستیک اسیدγ-aminobutyric acid - اسید γ-آمینوبوتیریکBAPTA - بیایپیتیایtetrodotoxin - تترو دوتوکسین Time constant - ثابت زمانیTau - خود راDevelopment - رشدinterspike interval - فاصله interterspeedLin - لینartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیMibefradil - میببرادیلhigh-voltage-activated - ولتاژ بالا فعال شده استaction potential - پتانسیل عمل TEA - چایHVA - چهLow-voltage-activated - کم ولتاژ فعالGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Role of low-voltage-activated calcium current and extracellular calcium in controlling the firing pattern of developing CA1 pyramidal neurons Role of low-voltage-activated calcium current and extracellular calcium in controlling the firing pattern of developing CA1 pyramidal neurons](/preview/png/5737749.png)
چکیده انگلیسی
The firing pattern of individual neurons is an important element for information processing and storing. During the first weeks of development, there is a transitional period during which CA1 pyramidal neurons display burst-spiking behavior in contrast to the adult regular-firing pattern. Spike after-depolarizations (ADPs) constitute a major factor underlying burst-spiking behavior. Using current-clamp recordings, we studied ADP waveforms and firing patterns in CA1 pyramidal neurons of Wistar rats from 9 to 19 postnatal days (P9-19). The percentage of burst-spiking neurons increased up to P16, in correlation with the emergence of an active component in the ADP. The application of low-voltage-activated (LVA) calcium channel blockers such as nickel or mibefradil suppressed the generation of the active ADP component and burst-spiking behavior. In agreement with the development of the ADP waveform and burst-spiking behavior, voltage-clamp experiments in dissociated pyramidal neurons showed an increase in the LVA calcium current in P16-19 vs P9-12. Finally, we found that a reduction of extracellular calcium levels decreases the percentage of burst-spiking cells due to a reduction in the active component of the ADP. We conclude that a major contribution of LVA calcium channels to ADP determines the bursting capability of CA1 pyramidal neurons during a transitional postnatal period in contrast to adulthood.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 344, 6 March 2017, Pages 89-101
Journal: Neuroscience - Volume 344, 6 March 2017, Pages 89-101
نویسندگان
Alberto Sánchez-Aguilera, José Luis Sánchez-Alonso, MarÃa Ángeles Vicente-Torres, Asunción Colino,