کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5737758 | 1614732 | 2017 | 55 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Auditory hindbrain atrophy and anomalous calcium binding protein expression after neonatal exposure to monosodium glutamate
ترجمه فارسی عنوان
آتروفی قلبی متابولیک و بیان پروتئین مرتبط با کلسیم غیرمستقیم بعد از قرار گرفتن نوزادان با گلوتامات مونون سدیم
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کلمات کلیدی
DCNMSGMSOLSOMNTBAVCNfourth ventricle - بطن چهارمlateral superior olive - زیتون برتر جانبیmedial superior olive - زیتون عالیconfidence interval - فاصله اطمینانanterior ventral cochlear nucleus - هسته حلقوی شکمی قدامیmedial nucleus of the trapezoid body - هسته مرکزی بدن تراپزیdorsal cochlear nucleus - هسته کچلی پشتیCalretinin - کالورتینینcalbindin - کلبیندینmonosodium glutamate - گلوتامات monosodium
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Glutamate is the most abundant excitatory neurotransmitter in the central nervous system, and is stored and released by both neurons and astrocytes. Despite the important role of glutamate as a neurotransmitter, elevated extracellular glutamate can result in excitotoxicity and apoptosis. Monosodium glutamate (MSG) is a naturally occurring sodium salt of glutamic acid that is used as a flavor enhancer in many processed foods. Previous studies have shown that MSG administration during the early postnatal period results in neurodegenerative changes in several forebrain regions, characterized by neuronal loss and neuroendocrine abnormalities. Systemic delivery of MSG during the neonatal period and induction of glutamate neurotoxicity in the cochlea have both been shown to result in fewer neurons in the spiral ganglion. We hypothesized that an MSG-induced loss of neurons in the spiral ganglion would have a significant impact on the number of neurons in the cochlear nuclei and superior olivary complex (SOC). Indeed, we found that exposure to MSG from postnatal days 4 through 10 resulted in significantly fewer neurons in the cochlear nuclei and SOC and significant dysmorphology in surviving neurons. Moreover, we found that neonatal MSG exposure resulted in a significant decrease in the expression of both calretinin and calbindin. These results suggest that neonatal exposure to MSG interferes with early development of the auditory brainstem and impacts expression of calcium binding proteins, both of which may lead to diminished auditory function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 344, 6 March 2017, Pages 406-417
Journal: Neuroscience - Volume 344, 6 March 2017, Pages 406-417
نویسندگان
Lindsey Foran, Kaitlyn Blackburn, Randy J. Kulesza,