کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5737854 | 1614733 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential response to intrahippocampal interleukin-4/interleukin-13 in aged and exercise mice
ترجمه فارسی عنوان
پاسخ دیفرانسیل به اینترلوکین-4 / اینترلوکین 13 در داخل موش های سالم و ورزش
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کلمات کلیدی
PBSFIZZ1LPSTGF-βTNFIGFTBIYm1IL-1RASOCSs.c.RT-PCRARG1BDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز Arginase-1 - آرژنین 1Traumatic brain injury - آسیب تروماتیک مغزIL-1 receptor antagonist - آنتاگونیست گیرنده IL-1interleukin - اینترلوکینtransforming growth factor-β - تبدیل فاکتور رشد βstandard error of the mean - خطای استاندارد میانگینsubcutaneous - زیر جلدیsuppressor of cytokine signaling - سرکوب کننده سیگنالینگ سیتوکینCytokine - سیتوکینAnti-inflammatory - ضدالتهابbrain derived neurotrophic factor - عامل مغز استخوان مغز استخوان استInsulin-like growth factor - فاکتور رشد مانند انسولینtumor necrosis factor - فاکتور نکروز تومورlipopolysaccharide - لیپوپلی ساکاریدPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریSEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیMicroglia - میکروگلیاهاreal-time polymerase chain reaction - واکنش زنجیره ای پلیمراز واقعی در زمان واقعیwheel running - چرخ در حال اجراfound in inflammatory zone 1 - یافت شده در منطقه التهابی 1
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Normal aging is associated with low-grade neuroinflammation that results from age-related priming of microglial cells. Further, aging alters the response to several anti-inflammatory factors, including interleukin (IL)-4 and IL-13. One intervention that has been shown to modulate microglia activation in the aged brain, both basally and following an immune challenge, is exercise. However, whether engaging in exercise can improve responsiveness to anti-inflammatory cytokines is presently unknown. The current study evaluated whether prior exercise training increases sensitivity to anti-inflammatory cytokines that promote the M2 (alternative) microglia phenotype in adult (5-month-old) and aged (23-month-old) C57BL/6J mice. After 8 weeks of exercise or control housing, mice received bilateral hippocampal injections of an IL-4/IL-13 cocktail or vehicle. Twenty-four hours later hippocampal samples were collected and analyzed for expression of genes associated with the M1 (inflammatory) and M2 microglia phenotypes. Results show that IL-4/IL-13 administration increased expression of the M2-associated genes found in inflammatory zone 1 (Fizz1), chitinase-like 3 (Ym1), Arginase-1 (Arg1), SOCS1, IL-1ra, and CD206. In response to IL-4/IL-13 administration, aged mice showed increased hippocampal expression of the M2-related genes Arg1, SOCS1, Ym1, and CD206 relative to adult mice. Aged mice also showed increased expression of IL-1β relative to adults, which was unaffected by wheel running or IL-4/IL-13. Wheel running was found to have modest effects on expression of Ym1 and Fizz1 in aged and adult mice. Collectively, our findings indicate that aged mice show a differential response to anti-inflammatory cytokines relative to adult mice and that exercise has limited effects on modulating this response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 343, 20 February 2017, Pages 106-114
Journal: Neuroscience - Volume 343, 20 February 2017, Pages 106-114
نویسندگان
Alyssa Littlefield, Rachel A. Kohman,