کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5738278 1615043 2017 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rutin alleviates chronic unpredictable stress-induced behavioral alterations and hippocampal damage in mice
ترجمه فارسی عنوان
روتن دچار تغییرات رفتاری ناشی از استرس ناشی از شدت مزمن و آسیب هیپوکامپ در موش
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Chronic stress results in neurological complications like depression, cognitive dysfunction, and anxiety disorders. In our previous study, we observed that Urtica dioica leaf extract attenuated chronic stress-induced complications. Further, we observed that Urtica dioica contained a great amount of the flavonoid rutin in it. Hence, we aimed to evaluate the effect of rutin on 21 days chronic unpredictable stress (CUS) mouse model. CUS led to a decline in locomotion & muscle coordination abilities, cognitive deficits, anxiety, and depression. These neurobehavioral outcomes were associated with neurodegeneration in the CA3 region of the hippocampus as found by H&E staining. Rutin efficiently rescued the CUS-induced behavioral deficits by reducing depression, anxiety, improving cognition, and locomotor & muscle coordination skills. Further, rutin treatment protected the CUS-induced hippocampal neuronal loss. This study establishes the neuroprotective effect of rutin in chronic stress.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 656, 24 August 2017, Pages 65-71
نویسندگان
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