کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5738305 | 1615044 | 2017 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Streptozocin-induced type-1 diabetes mellitus results in decreased density of CGRP sensory and TH sympathetic nerve fibers that are positively correlated with bone loss at the mouse femoral neck
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کلمات کلیدی
IGFtBMDTb.NTb.SpTb.ThT1DMT2DMSTZCGRPInnervationmicroCTNGFTNF alpha - آلفا TNFStreptozocin - استرپتوزوکینtrabecular bone mineral density - تراکم استخوان معدن چگالیtyrosine hydroxylase - تیروزین هیدروکسیلازtrabecular separation - جداسازی ترابکولارDegree of anisotropy - درجه ناهنجاریType-1 diabetes mellitus - دیابت نوع 1type-2 diabetes mellitus - دیابت نوع 2trabecular number - شماره تراککالHip-fracture - شکستگی لگنtrabecular thickness - ضخامت تراککالInsulin growth factor-1 - عامل رشد انسولین- 1nerve growth factor - فاکتور رشد عصبtumor necrosis factor - فاکتور نکروز تومورOsteoporosis - پوکی استخوانcalcitonin gene-related peptide - پپتید مرتبط با ژن کلسی تونین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Type-1 diabetes mellitus (T1DM) results in loss of innervation in some tissues including epidermis and retina; however, the effect on bone innervation is unknown. Likewise, T1DM results in pathological bone loss and increased risk of fracture. Thus, we quantified the density of calcitonin gene-related peptide (CGRP+) sensory and tyrosine hydroxylase (TH+) sympathetic nerve fibers and determined the association between the innervation density and microarchitecture of trabecular bone at the mouse femoral neck. Ten weeks-old female mice received 5 daily administrations of streptozocin (i.p. 50Â mg/kg) or citrate (control group). Twenty weeks later, femurs were analyzed by microCT and processed for immunohistochemistry. Confocal microscopy analysis revealed that mice with T1DM had a significant loss of both CGRP+ and TH+ nerve fibers in the bone marrow at the femoral neck. Likewise, microCT analysis revealed a significant decrease in the trabecular bone mineral density (tBMD), bone volume/total volume ratio (BV/TB), trabecular thickness (Tb.Th), trabecular number (Tb.N) and trabecular separation (Tb.Sp) in mice with T1DM as compared to control mice. Analysis of correlation revealed a positive and significant association between density of CGRP+ or TH+ nerve fibers with tBMD, BV/TV, Tb.Th and Tb.Sp, but not with trabecular number (there was a positive association only for CGRP+) and degree of anisotropy (DA). This study suggests an interaction between sensory and sympathetic nervous system and T1DM-induced bone loss. Identification of the factors involved in the loss of CGRP+ sensory and TH+ sympathetic fibers and how they regulate bone loss may result in new avenues to treat T1DM-related osteoporosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 655, 10 August 2017, Pages 28-34
Journal: Neuroscience Letters - Volume 655, 10 August 2017, Pages 28-34
نویسندگان
Iris A. EnrÃquez-Pérez, Karla E. Galindo-Ordoñez, Christian E. Pantoja-OrtÃz, Arisaà MartÃnez-MartÃnez, Rosa I. Acosta-González, Enriqueta Muñoz-Islas, Juan M. Jiménez-Andrade,