کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5738357 | 1615049 | 2017 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sleep deprivation accelerates the progression of alzheimer's disease by influencing Aβ-related metabolism
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Sleep disorders have previously been connected with the neurodegenerative pathology of Alzheimer's disease (AD) due to the aggregation of β-amyloid(Aβ)peptides and tau proteinsinduced by sleep deprivation (SD). However, the underlying mechanisms remain unclear. Therefore, this study was performed to clarify how Aβ-related metabolism is regulated after SD. Three-month-old Sprague-Dawley rats (250-300 g) were randomly divided into 5 groups: two SD groups(i.e.,SD-2d and SD-4d), two platform control groups(i.e.,PC-2d and PC-4d) and a home cage control group (CC). For the two SD groups, themodified multiple platform method (MMPM) was used to induce SD.Our experiments confirmed that SD impaired cognitive function and increased the levels of Aβ peptides, a hallmark of AD. Additionally, we found that SD significantly increasedthe levels of the β-site amyloid precursor protein (APP)-cleaving enzyme 1(BACE1, β-secretase), but had little impacton the levels of Aβ-degradationenzymes.This resultmay be the main cause of the over-expression of Aβ1-42 and Aβ1-40. Our results suggested that SD accelerates the progression of AD bymodulating Aβ-related metabolism. This findinghasimportant implications for the diagnosis and prevention of AD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 650, 22 May 2017, Pages 146-152
Journal: Neuroscience Letters - Volume 650, 22 May 2017, Pages 146-152
نویسندگان
Lihong Chen, Junshan Huang, Lanfang Yang, Xue-Ai Zeng, Ya Zhang, Xiufeng Wang, Mingqi Chen, Xing Li, Yifan Zhang, Min Zhang,