کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5738828 | 1615059 | 2017 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Serotonin 5-HT4 receptors modulate the development of glutamatergic input to the dorsal raphe nucleus
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Serotonin 5-HT4 receptors modulate the development of glutamatergic input to the dorsal raphe nucleus Serotonin 5-HT4 receptors modulate the development of glutamatergic input to the dorsal raphe nucleus](/preview/png/5738828.png)
چکیده انگلیسی
The dorsal raphe nucleus (DRN) is a major serotonin (5-hydroxytryptamine, 5-HT)-producing region in the central nervous system. It receives glutamatergic inputs from several brain regions, which are reciprocally modulated by serotonergic signals. We investigated whether serotonin 5-HT4 receptors (5-HT4Rs) play a role in the development of glutamatergic control of the DRN, with an emphasis on cortical inputs. Double-label immunohistochemistry and confocal microscopy were used to quantify vesicular glutamate transporter 1 (vGluT1)-immunoreactive terminals in the DRN of mice with a null-mutation in the 5-HT4R gene. We found no significant change in the overall density of vGluT1-positive terminals in homozygous and heterozygous mice, but heterozygous mice had a significantly higher density of vGluT1-positive terminals contacting serotonergic neurons. These results suggest that altered 5-HT4R expression may affect the development of cortical glutamatergic control of the DRN.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 640, 15 February 2017, Pages 111-116
Journal: Neuroscience Letters - Volume 640, 15 February 2017, Pages 111-116
نویسندگان
Angela Chen, Katherine D. Hubbert, Pasha F. Foroudi, Vivian F. Lu, Skirmantas Janušonis,