کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5738885 1615062 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Insight gained from genome-wide interaction and enrichment analysis on weight gain during citalopram treatment
ترجمه فارسی عنوان
بینش حاصل از تعامل ژنوم و تجزیه و تحلیل غنی سازی در افزایش وزن در طی درمان سیالوپرام
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Weight gain is a possible side effect of the pharmacological antidepressant treatments. Defining antidepressant prescriptions based on personal genetic makeups would decrease the risk of weight gain and increase the quality of the current antidepressant pharmacological treatments. 643 depressed, citalopram treated individuals with available clinical and genome-wide genetic information were investigated to identify the molecular pathways associated with weight gain. 111 individuals experienced weight gain during citalopram treatment. The axon guidance (p.adjust = 0.005) and the developmental biology pathway (p.adjust = 0.01) were enriched in variations associated with weight gain. The developmental biology pathway includes molecular cascades involved in the regulation of beta-cell development, and the transcriptional regulation of white adipocyte differentiation. A number of variations were harbored by genes whose products are involved in the synthesis of collagen (COL4A3, COL5A1 and ITGA1), activity of the thyroid-hormones (NCOR1 and NCOR2), energy metabolism (ADIPOQ, PPARGC1A) and myogenic differentiation (CDON). A molecular pathway analysis conducted in a sample of depressed patients identified new candidate genes whose future investigation may provide insights in the molecular events that drive weight gain during antidepressant treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 637, 10 January 2017, Pages 38-43
نویسندگان
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