کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5738900 | 1615062 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Brain and intestinal expression of galanin-like peptide (GALP), galanin receptor R1 and galanin receptor R2, and GALP regulation of food intake in goldfish (Carassius auratus)
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کلمات کلیدی
intracerebroventricularPFAMS-222DAPINPYCCKICVNRLNATFasciculus retroflexusCARTGALPPBSNPPVOTEC4′,6-diamidino-2-phenylindole - 4 '، 6-دیامیدینو-2-فنیلینولtorus longitudinalis - longitudinalis torusImmunohistochemistry - ایمونوهیستوشیمیIHC - ایمونوهیستوشیمیFeeding - تغذیهcocaine- and amphetamine-regulated transcript - دستورالعمل تنظیم شده کوکائین و آمفتامینSubmucosa - زیربوسیOptic tectum - سقف نوریArc - قوسFish - ماهیPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریmucosa - مخاطBrain - مغزanterior tuberal nucleus - هسته سلول قدامیarcuate nucleus - هسته قوسbody weight - وزن بدنparaformaldehyde - پارافرمالدهیدgalanin-like peptide - پپتید مانند گالانینcholecystokinin - کولهسیستوکینینGut - گل سرخNeuropeptide Y - یوروپروتئین Y
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Brain and intestinal expression of galanin-like peptide (GALP), galanin receptor R1 and galanin receptor R2, and GALP regulation of food intake in goldfish (Carassius auratus) Brain and intestinal expression of galanin-like peptide (GALP), galanin receptor R1 and galanin receptor R2, and GALP regulation of food intake in goldfish (Carassius auratus)](/preview/png/5738900.png)
چکیده انگلیسی
Galanin-like peptide (GALP) is a 60 amino acid neuropeptide originally discovered from porcine hypothalamus, and is involved in the regulation of food intake in mammals. Since its discovery, GALP and its receptors (GALR1 and GALR2) have been characterized in mammals, but no publications are available on GALP in fish and other non-mammals. The present study aimed to characterize brain and intestinal GALP and its receptors using immunohistochemistry in a teleost, the goldfish (Carassius auratus), and to study its effects on feeding behavior. Immunostaining of brain sections shows the presence of GALP- and GALR1- and GALR2-like immunoreactive cells in different encephalic areas, including the telencephalon, some hypothalamic nuclei, the optic tectum, the torus longitudinalis and the cerebellum. Signal for GALP was also observed in the fasciculus retroflexus. In the gut, GALP-and GALR1 and GALR2 immunoreactive cells were detected in the mucosa. Results from the feeding study demonstrate that intracerebroventricular administration of GALP (1Â ng/g bodyweight) increases goldfish food intake at 1Â h post-injection. These observations form the first report on the presence of GALP in the fish brain and gut, and also on its modulatory role on fish feeding behavior. GALP, as in mammals, appears to be a functional neuropeptide in goldfish.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 637, 10 January 2017, Pages 126-135
Journal: Neuroscience Letters - Volume 637, 10 January 2017, Pages 126-135
نویسندگان
Elsie Tachie Mensah, Ayelén Melisa Blanco, Andrew Donini, Suraj Unniappan,