کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5748356 1619026 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Season-dependent concentrations of urinary phthalate metabolites among Chinese pregnant women: Repeated measures analysis
ترجمه فارسی عنوان
غلظت وابسته به فصل متابولیت های فتالات ادرار در زنان باردار چینی: تجزیه و تحلیل اندازه گیری های تکراری
کلمات کلیدی
متابولیت های فتالات زنان حامله، تولد همسر، تجزیه و تحلیل اندازه گیری تکرار، چین،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
چکیده انگلیسی


- Phthalate exposure is prevalent in Chinese pregnant women.
- Coexposure to multiple phthalates at high-doses is infrequent among Chinese pregnant women.
- Throughout pregnancy exposure to one specific phthalate at high-dose is infrequent.
- Exposure to phthalates during pregnancy is mild to moderate temporal stability.
- Urinary levels of all the phthalate metabolites vary by sampling seasons.

In utero exposure to phthalates may have adverse effects on pregnant women and their offsprings. Therefore, the exposure level of these substances among individuals, particularly among sensitive population, is of concern. The objective of the present study is to characterize urinary concentrations of phthalate metabolites at multiple time points during pregnancy in Chinese women. A total of 3455 pregnant women were included from Ma'anshan Birth Cohort in China. Spot urine samples in the morning (8:00-10:00) and questionnaires were obtained at three separate visits (approximately in 10, 26, and 34 gestational weeks). Seven phthalate metabolites from urine samples were analyzed, including monomethyl phthalate (MMP), monoethyl phthalate (MEP), monobutyl phthalate (MBP), mono benzyl phthalate (MBzP), mono-2-ethylhexyl phthalate (MEHP), mono (2-ethyl-5-oxohexyl) phthalate (MEOHP) and mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP). Geometric means of concentrations were ranged from 0.05 to 41.0 ng/mL for all the metabolites mentioned above. No individual exposure level was above the 95th percentiles for all the seven phthalates. On the three separate visits, 0.5%, 0.9% and 1.2% of the participants had coexposure to above the 75th percentiles for all metabolites. Taken these visits together, a total of 29 urine samples had concentrations above the 95th percentiles, while 3.0%-5.6% of urine levels were above 75th percentiles for at least one specific phthalate metabolite. We observed moderate intraclass correlation coefficients (ICCs) ranging from 0.44 to 0.56 for MBzP, MEHP and MEP, and lower ICCs, from 0.28 to 0.32, for MMP, MBP, MEOHP and MEHHP. Sampling season was associated with concentrations of all phthalate metabolites, showing heavier exposure was more likely to occur during summer. In summary, phthalate exposure is prevalent in Chinese pregnant women. However, throughout pregnancy coexposure to multiple phthalates at the upper percentile of exposure is infrequent. Mild to moderate temporal stability indicates that a single measurement in spot urine collected in the morning (8:00-10:00) seems not enough to describe throughout pregnancy phthalate exposure. Urinary levels vary by sampling seasons, which should be taken into consideration in future analyses.

The unadjusted and creatinine-adjusted concentrations of urinary phthalate metabolites.132

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environment International - Volume 104, July 2017, Pages 110-117
نویسندگان
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