Hormesis commonly observed in the assessment of aneuploidy in yeast

- Hormesis occurred commonly for chemically induced aneuploidy.
- An estimate of the frequency of hormesis for aneuploidy is provided.
- Findings suggest that hormesis should be evaluated for other genotoxic endpoints.

Extensive dose response studies have assessed the potential of toxic chemical agents to induce aneuploidy in the yeast model. An assessment of such findings revealed that hormetic-like biphasic dose responses were commonly observed. A preliminary estimate of the frequency of the hormetic responses using a priori entry and evaluative criteria was approximately 65-80%.

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