کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5750847 1619702 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Study of trace metal imbalances in the blood, scalp hair and nails of oral cancer patients from Pakistan
ترجمه فارسی عنوان
مطالعه عدم تعادل فلزات ردیابی در خون، موی سر و ناخن بیماران مبتلا به سرطان دهان از پاکستان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
چکیده انگلیسی


- The study investigates the disproportion of trace metals in oral cancer patients.
- Concentrations of Cd, Ni and Pb were found significantly higher in the patients.
- Correlations among trace metals were significantly diverse in the patients/control.
- CA showed interferences by trace metals in blood, hair and nails of the patients.
- Trace metals showed considerable variations for various cancer stages and types.

Oral cancer is an important cause of cancer morbidity and mortality globally and exposure to trace metals alongside tobacco, alcohol and HPV are the important etiological factors in its development. Selected essential and toxic trace metals (Cd, Cr, Cu, Fe, Mn, Ni, Pb and Zn) were measured in the blood, scalp hair and nails of oral cancer patients and counterpart controls by atomic absorption spectrometry. Mean concentrations of Cd, Ni and Pb were found to be significantly higher (p < 0.05) and those of Cu, Fe and Zn were considerably lower in the blood, scalp hair and nails of the patients than the controls. Most of the metal concentrations exhibited higher dispersion and asymmetry in the blood, scalp hair and nails of the patients compared with the controls. The correlation study revealed significantly diverse relationships among the metals in blood, scalp hair and nails of both donor groups. Variations in the metal levels were also noted for various stages (I, II, III & IV) as well as the types (adenocarcinoma and squamous cell carcinoma) of oral cancer. Multivariate cluster analysis of the metal levels in the patients were also significantly dissimilar than the controls. The study evidenced considerably divergent variations in the metal levels in oral cancer patients in comparison with the controls.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Science of The Total Environment - Volumes 593–594, 1 September 2017, Pages 191-201
نویسندگان
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