کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
575418 | 1453052 | 2016 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mitochondrial dysfunction induced by ultra-small silver nanoclusters with a distinct toxic mechanism
ترجمه فارسی عنوان
اختلال عملکرد میتوکندری ناشی از نانوکیلرهای نقره فوق نازک با مکانیسم سمی مجزا
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
نانوکیلرهای فلز نجیب، نانوذرات فوق فوق نازک، اثر بیولوژیک، میتوکندریا، انتقال نفوذپذیری میتوکندری،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بهداشت و امنیت شیمی
چکیده انگلیسی
As noble metal nanoclusters (NCs) are widely employed in nanotechnology, their potential threats to human and environment are relatively less understood. Herein, the biological effects of ultra-small silver NCs coated by bovine serum albumin (BSA) (Ag-BSA NCs) on isolated rat liver mitochondria were investigated by testing mitochondrial swelling, membrane permeability, ROS generation, lipid peroxidation and respiration. It was found that Ag-BSA NCs induced mitochondrial dysfunction via synergistic effects of two different ways: (1) inducing mitochondrial membrane permeability transition (MPT) by interacting with the phospholipid bilayer of the mitochondrial membrane (not with specific MPT pore proteins); (2) damaging mitochondrial respiration by the generation of reactive oxygen species (ROS). As far as we know, this is the first report on the biological effects of ultra-small size nanoparticles (â¼2Â nm) at the sub-cellular level, which provides significant insights into the potential risks brought by the applications of NCs. It would inspire us to evaluate the potential threats of nanomaterials more comprehensively, even though they showed no obvious toxicity to cells or in vivo animal models. Noteworthy, a distinct toxic mechanism to mitochondria caused by Ag-BSA NCs was proposed and elucidated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hazardous Materials - Volume 308, 5 May 2016, Pages 139-148
Journal: Journal of Hazardous Materials - Volume 308, 5 May 2016, Pages 139-148
نویسندگان
Ping Dong, Jia-Han Li, Shi-Ping Xu, Xiao-Juan Wu, Xun Xiang, Qi-Qi Yang, Jian-Cheng Jin, Yi Liu, Feng-Lei Jiang,