کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
575750 1453060 2015 43 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Decreased spermatogenesis led to alterations of testis-specific gene expression in male mice following nano-TiO2 exposure
ترجمه فارسی عنوان
کاهش اسپرماتوژنز منجر به تغییرات بیان ژن اختصاصی بیضه در موشهای نر به دنبال نانو تیوی 2
کلمات کلیدی
نانوذرات دی اکسید تیتانیوم، موش، اسپرماتوژنز، ژن های خاص تست،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بهداشت و امنیت شیمی
چکیده انگلیسی
Although TiO2 nanoparticles (NPs) exposure has been demonstrated to cross blood-testis barrier and accumulate in the testis resulting in the reduction of sperm numbers, limited data with respect to the molecular mechanism of decreased spermatogenesis caused by TiO2 NP exposure. In this research, testicular damage, sperm number and alterations in testis-specific gene expressions in male mice induced by intragastric administration with TiO2 NPs for six months were investigated. It was found out that TiO2 NPs could migrate to cells, deposit in the testis and epididymis and thus cause damages to relevant organs, which are, to be more specific, the reductions of total sperm concentrations and sperm motility and an enhancement in the number of abnormal sperms in the cauda epididymis. Furthermore, the individual expression regarding to the mRNAs and proteins of testis-specific genes, including Cdc2, Cyclin B1, Dmcl, TERT, Tesmin, TESP-1, XPD and XRCCI, were significantly declined, whereas Gsk3-β and PGAM4 expressions were greatly elevated in mouse testis due to the exposures, which in fact implied that the reduced spermatogenesis may be involved in the alternated testis-specific gene expressions in those exposed male mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hazardous Materials - Volume 300, 30 December 2015, Pages 718-728
نویسندگان
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