The effect of novel magnetic nanoparticles on vascular endothelial cell function in vitro and in vivo

► The novel nanoparticles could internalize in HUVEC and diffuse in the cytoplasm. ► 1-200 μg/ml MNPs did not affect HUVECs and could be safe to HUVECs in vitro. ► 400 μg/ml MNPs inhibited cell growth regulated by caveolin-1 and eNOS. ► 20 mg/kg MNPs damaged endothelium in the aortic root after injected for 3 days. ► After injected for 6 days and 9 days, the endothelium recovered the integrity.