کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5789275 1414308 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
O-linked β-N-acetylglucosamine modification and its biological functions
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
O-linked β-N-acetylglucosamine modification and its biological functions
چکیده انگلیسی
The covalent attachment of O-linked β-N-acetylglucosamine (O-GlcNAc) to Ser/Thr residues of proteins acts as not only a posttranslational modification but also a nutritional sensor in nucleus and cytoplasm, which directly regulates the expression of genes and multiple crucial signal transduction pathways. Dynamic O-GlcNAcylation at Ser/Thr residues is catalyzed by two key enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase, which are responsible for addition and removal of the O-GlcNAc modification, respectively. O-GlcNAc modification plays important roles in cellular signaling in animals, especially in human diseases. Two orthologs of OGT in plants, SECRET AGENT and SPINDLY, have been reported to be involved in diverse plant processes. However, compared with the functional mechanisms revealed in animals, the consequences of protein O-GlcNAc modification in plants is largely unknown, and the relationship between O-GlcNAcylation and cellular processes needs to be explored. In this review, we summarized the recent advances on O-GlcNAc modification and its biological functions in animals and plants, and prospect of more special functions of O-GlcNAc will be revealed in plants.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Science Bulletin - Volume 60, Issue 12, June 2015, Pages 1055-1061
نویسندگان
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