کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5794080 | 1554189 | 2012 | 4 صفحه PDF | دانلود رایگان |
Erythromycin is an antimicrobial agent recommended for the control and treatment of diseases caused by Gram-positive bacteria. Few studies, however, have determined the metabolic and pharmacokinetic aspects of this antimicrobial agent in fish. The aim of the present study, therefore, was to determine the accumulation and depletion time of erythromycin after administration of medicated feed containing 52 mg kgâ1 body weight dayâ1 for 8 days in rainbow trout (Oncorhynchus mykiss). Results were analyzed following the European Agency for Evaluation of Medicinal Products guidelines. We measured a withdrawal time of 187 °C-day (°C-day = water temperature Ã days), lower than the value (500 °C-day) recommended by Council Directive 2004/28/EC for veterinary medicinal products. Our results provide data to establish therapeutic regimens for the use of erythromycin in aquaculture.
Journal: Preventive Veterinary Medicine - Volume 105, Issues 1â2, 1 June 2012, Pages 160-163