Plasma cytokine levels in dogs undergoing cardiopulmonary bypass

- We investigated whether cardiopulmonary bypass become a trigger of systemic inflammatory response in dogs.
- We analyzed plasma levels of interleukin-6 (IL-6), tissue necrosis factor-α (TNF-α), interleukin-10 (IL-10), white blood cells (WBC), and C-reactive protein (CRP).
- After CPB, plasma levels of IL-6, WBC counts, and CRP levels were significantly higher than preoperative levels.
- CPB induced a systemic inflammatory response in dogs.

Currently, there are no reports of inflammatory responses to CPB in dogs. We investigated the time course of pro- and anti-inflammatory cytokine levels during and after CPB.AnimalsThe study group included 11 dogs that underwent mitral valve repair with CPB, and the control group included 7 healthy dogs that underwent ovariohysterectomy.MethodsBlood samples from the study group dogs were collected before, during and after surgery and analyzed for plasma levels of interleukin-6 (IL-6), tissue necrosis factor-α (TNF-α), interleukin-10 (IL-10), white blood cells (WBC), and C-reactive protein (CRP). Each inflammatory parameter was also compared with that of the control group dogs.ResultsAfter CPB, plasma levels of IL-6, WBC counts, and CRP levels were significantly higher than preoperative levels, and IL-6 levels in the study group were significantly higher than those in the control group.ConclusionsCPB induces a systemic inflammatory response in dogs.

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