کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5805733 1555722 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Disturbance of oxidant/antioxidant equilibrium in horses naturally infected with Trypanosoma evansi
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Disturbance of oxidant/antioxidant equilibrium in horses naturally infected with Trypanosoma evansi
چکیده انگلیسی

Oxidant/antioxidant equilibrium disturbance has already been reported in trypanosome infections by several authors. The present study was aimed to explore the possible oxidant/antioxidant disturbance in surra of naturally infected horses before and after treatment. Fifteen naturally infected horses were chosen to analyse erythrocytic indices, platelet counts, lipid peroxides (LPO), nitric oxide (NO), reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) while six healthy animals acted as control. There was a highly significant (P < 0.001) reduction in red blood cell (RBC) count, haemoglobin (Hb), packed cell volume (PCV) and platelet levels and a significant reduction in mean corpuscular haemoglobin concentration (MCHC) (P < 0.05) was noticed. A highly significant increase in NO (P < 0.001), a significant increase in LPO (P < 0.05) and a significant decrease in GSH, SOD and CAT (P < 0.05) were found. A negative correlation of RBC count with LPO (r = −0.844) and nitrate (r = −0.702) while a positive correlation with GSH (r = 0.489), SOD (r = 0.580) and CAT (r = 0.689) was observed. All the animals were treated with Quinapyramine sulphate (3 mg/kg s.c.) only once. Nine animals recovered completely without any side effects. The recovered animals were monitored and samples were collected every seven days for up to 21 days and parameters were analysed. After treatment, a significant increase in haematological parameters was noticed whereas the oxidative indices varied without any statistical significance. To conclude, the increase in oxidant parameters and decrease in antioxidant enzymes in infected horses indicates the disturbance of oxidant/antioxidant indices. There was a significant increase in post therapy haematological values, while the oxidant/antioxidant indices changed insignificantly indicating that antioxidants might be supplemented in the therapeutic regimen.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Parasitology - Volume 180, Issues 3–4, 25 August 2011, Pages 349-353
نویسندگان
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