Separation of emetic and anorexic responses of exendin-4, a GLP-1 receptor agonist in Suncus murinus (house musk shrew)

► Nausea and vomiting are common side effects associated with GLP-1 receptor agonists. ► Administration of exendin-4 induces emesis and inhibits feeding in Suncus murinus. ► Exendin-4 may exert its effects via the hypothalamus and brainstem. ► Central GLP-1 receptors may represent an important physiological mediator of satiety and emesis.