Influence of GluN2 subunit identity on NMDA receptor function

► Reviews the control of NMDAR functional properties by GluN2 subunits. ► Assesses structural elements of GluN2 subunits that determine NMDAR heterogeneity. ► Considers the utility of orthosteric and allosteric ligands acting at NMDARs. ► Potential of the NMDAR C-terminal domain as a novel therapeutic target is discussed.