کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5814827 1556639 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Invited reviewNMDA receptors in nervous system diseases
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Invited reviewNMDA receptors in nervous system diseases
چکیده انگلیسی


- NMDAR dysfunction as a common theme in nervous system disorders.
- Hyperactivity or hypofunction of NMDARs could contribute to disease pathophysiology.
- Excitotoxicity and influence on inhibition likely mediate NMDAR contribution.
- Subtypes of NMDARs (subunit and/or localization) may be differentially involved.

NMDA receptor (NMDAR) dysfunction has emerged as a common theme in several major nervous system disorders, including ischemic brain injury, chronic neurodegenerative diseases, pain, depression and schizophrenia. Either hyperactivity or hypofunction of NMDARs could contribute to disease pathophysiology. It is likely that distinct subtypes of NMDARs (as defined by subunit composition and/or subsynaptic location) are differentially involved in central nervous system diseases. Here we focus on a few examples of nervous system diseases where the contribution of NMDARs is relatively well characterized and discuss the implications for potential treatment of these illnesses.This article is part of the Special Issue entitled 'Glutamate Receptor-Dependent Synaptic Plasticity'.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 74, November 2013, Pages 69-75
نویسندگان
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