mGlu2/3 and mGlu5 receptors: Potential targets for novel antidepressants

► Agents acting on mGlu2/3 and mGlu5 receptors exhibit antidepressant effects. ► mGlu2/3 and mGlu5 receptor antagonists share neural mechanisms with ketamine. ► mGlu2/3 and mGlu5 receptors are useful targets for drug discovery for depression.