Enhanced mGlu5-receptor dependent long-term depression at the Schaffer collateral-CA1 synapse of congenitally learned helpless rats

► First demonstration of changes in mGlu5-receptor dependent synaptic plasticity in congenitally learned helpless rats. ► Selective enhancement of mGlu5-dependent LTD in congenitally learned helpless rats. ► Selective increase in mGlu5 receptor expression in congenitally learned helpless rats. ► Selective increase in mGlu5 receptor function in congenitally learned helpless rats.