Etazolate, an α-secretase activator, reduces neuroinflammation and offers persistent neuroprotection following traumatic brain injury in mice

► The post-TBI levels of sAPPα were restored by etazolate treatment. ► Etazolate decreases IL-1β levels, cerebral oedema and microglial activation. ► Locomotor hyperactivity and memory deficit were attenuated by etazolate treatment. ► Etazolate protects olfactory bulb tissue in a persistent manner. ► The therapeutic window of etazolate is at least 2 h.