دانلود مقالات ISI درباره Sappα + ترجمه فارسی

ویژگی ها و نتایج داروها برای درمان ترکیبی به عنوان استراتژی چند هدفه ای برای مبارزه با بیماری آلزایمر

Features and outcomes of drugs for combination therapy as multi-targets strategy to combat Alzheimer's disease

Keywords: AD; Alzheimer's disease; Aβ; β-amyloid peptide; NFTs; neurofibrillary tangles; EOAD; early-onset AD; LOAD; late-onset AD; OMOT; One-molecule-one-target; ROS; reactive oxygen species; CDMT; Combination-drugs-multi-targets; BBB; blood brain barrier; DDT;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

پردازش پروتئین پیش ماده آمیلوئید و انرژی زیستی

Amyloid precursor protein processing and bioenergetics

Keywords: ABAD; Aβ binding alcohol dehydrogenase; AD; Alzheimer's disease; ADAM; A Disintegrin and metalloproteinase; AICD; APP intracellular domain; APH1; anterior pharynx-defective 1; APP; amyloid precursor protein; ATP; adenosine triphosphate; Aβ; amyloid be

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

در اواخر دوران زودرس در مورد آلودگی آلزایمر خیلی دیر نیست

Late running is not too late against Alzheimer's pathology

Keywords: Aβ; beta-amyloid; APP; amyloid precursor protein; BBB; blood-brain barrier; CTFβ; C-terminal fragment β of APP; sAPPα; soluble APP α fragment; Late physical activity; Alzheimer's disease; Neuroplasticity; Aβ metabolism; Inflammation & autophagy;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

بیماری آلزایمر به علت از دست دادن عملکرد: یک سنتز جدید از داده های موجود

Alzheimer's disease due to loss of function: A new synthesis of the available data

Keywords: Aβ; β-Amyloid peptide; Aβ40; 40-amino acid isoform of β-Amyloid peptide; Aβ42; 42-amino acid isoform of β-Amyloid peptide; Aβ42/Aβ40; ratio of measured steady-state levels of Aβ42 and Aβ40; AD; Alzheimer's Disease; AICD; APP intracellular domain

دانلود رایگان متن کامل مقاله ISI 78 صفحه سال انتشار : 2016 سفارش ترجمه

بیومارکرهای مایع مغزی نخاعی برای پیش آگهی نتایج درمان شناختی درازمدت در بیماران مبتلا به هیدروسفالی فشار طبیعی ایدیوپاتیک

Cerebrospinal fluid biomarkers for prognosis of long-term cognitive treatment outcomes in patients with idiopathic normal pressure hydrocephalus

Keywords: Aβ; amyloid-beta; iNPH; idiopathic normal pressure hydrocephalus; LPS; lumboperitoneal shunting; iNPHGS; iNPH Grading Scale; MMSE; Mini Mental State Examination; FAB; frontal assessment battery; TMT-A; trail making test part A; mRS; modified Rankin Scale

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

تاتو تثبیت شده توسط انسان، تولید آمیلوئید بتا را افزایش می دهد

Human secreted tau increases amyloid-beta production

Keywords: Secreted tau; Extracellular tau; eTau; Amyloid-beta (Aβ); Neuronal hyperactivity; Alzheimer's disease; Feed forward mechanism; sAPPα;

دانلود رایگان متن کامل مقاله ISI 63 صفحه سال انتشار : 2015 سفارش ترجمه

نشانگرهای ژنتیکی برای تشخیص و پاتوژنز بیماری آلزایمر

Genetic markers for diagnosis and pathogenesis of Alzheimer's disease

Keywords: AD; Alzheimer's disease; Aβ; amyloid β; Aph-1; anterior pharynx defective 1; AP; adaptor protein; APOE; apolipoprotein E; APP; amyloid precursor protein; AICD; amyloid intracellular domain; BACE-1; β-secretase beta-site amyloid precursor protein-cleavi

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

خط لوله مواد مخدر در تولید عصبی مبتنی بر مدل موش های ترانس ژنیک بیماری آلزایمر

Drug pipeline in neurodegeneration based on transgenic mice models of Alzheimer's disease

Keywords: 7,8-DHF; 7,8-dihydroxyflavone; Aβ; amyloid beta; AchE; acetylcholine-esterase; ABCA1; ATP-binding cassette transporter 1; APP; amyloid precursor protein; Akt; protein kinase B; ApoE; apolipoprotein E; AAV/Aβ; adeno-associated viral vector carrying Aβ c

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2013 سفارش ترجمه

Neuregulin 1 regulates amyloid precursor protein cell surface expression and non-amyloidogenic processing

Keywords: Amyloid-precursor protein; Neuregulin 1; Secreted APPα; Non-amyloidogenic processing; ADAM10; AD; Alzheimer's disease; APP; amyloid precursor protein; EGF; epithelial growth factor; ER; endoplasmic reticulum; NRG1; neuregulin; sAPPα; secreted APPα; s

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Targeting demyelination via α-secretases promoting sAPPα release to enhance remyelination in central nervous system

Keywords: Etazolate; α-Secretase; sAPPα; Myelin; Oligodendrocyte; De/remyelination; White matter;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2018 سفارش ترجمه

Oleocanthal-rich extra-virgin olive oil enhances donepezil effect by reducing amyloid-β load and related toxicity in a mouse model of Alzheimer's disease

Keywords: AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid precursor protein; ApoE; apo-lipoprotein E; ABCA1; ATP-binding cassette transporter A1; BBB; blood-brain barrier; EVOO; extra-virgin olive oil; GFAP; glial fibrillary acidic protein; IL-1β; inter

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

Profiles of β-Amyloid Peptides and Key Secretases in Brain Autopsy Samples Differ with Sex and APOE ε4 Status: Impact for Risk and Progression of Alzheimer Disease

Keywords: AD; Alzheimer disease; Aβ; β-amyloid; ADAM10; A disintegrin and metalloproteinase domain-containing protein 10/α-secretase (brain); APP; Amyloid Protein Precursor; APOE ε4; Apolipoprotein, allele epsilon4; BACE1; beta-site amyloid precursor protein cl

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2018 سفارش ترجمه

Research articleFormononetin attenuates Aβ25-35-induced cytotoxicity in HT22 cells via PI3K/Akt signaling and non-amyloidogenic cleavage of APP

Keywords: amyloid β; Aβ; Alzheimer's disease; AD; estrogen receptor α; ERα; formononetin; Form; soluble amyloid precursor protein α; sAPPα; Alzheimer's disease; β-amyloid; Formononetin; APP; ERα; PI3K/Akt;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Oleocanthal ameliorates amyloid-β oligomers' toxicity on astrocytes and neuronal cells: In vitro studies

Keywords: ABCA1; ATP-binding cassette transporter-A1; ACM; astrocyte-conditioned media; AD; Alzheimer's disease; ApoE; apolipoprotein E; APP; amyloid precursor protein; Aβ; amyloid-β; Aβm; Aβ monomer; Aβo; Aβ oligomers; BBB; blood-brain barrier; BSA; bovi

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Astrocytes regulate α-secretase-cleaved soluble amyloid precursor protein secretion in neuronal cells: Involvement of group IIA secretory phospholipase A2

Keywords: AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid-β peptide; BACE1; β-site APP cleaving enzyme; BSA; bovine serum albumin; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; FBS; fetal bovine serum; FCVJ; Farne

دانلود رایگان متن کامل مقاله ISI 61 صفحه سال انتشار : 2015 سفارش ترجمه

The E1 copper binding domain of full-length amyloid precursor protein mitigates copper-induced growth inhibition in brain metastatic prostate cancer DU145 cells

Keywords: Aβ; amyloid beta; AD; Alzheimer's disease; APP; amyloid precursor protein; BACE1; beta-site APP-cleaving enzyme 1; CuBD; copper binding domain; ICD; intracellular domain; PCa; prostate cancer; sAPPα; soluble APP alpha; sAPPβ; soluble APP beta; SDS-

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Metallothionein-III increases ADAM10 activity in association with furin, PC7, and PKCα during non-amyloidogenic processing

Keywords: APP; amyloid precursor protein; MT-III; metallothionein-III; sAPPα; soluble APPα; AD; Alzheimer's disease; Aβ; amyloid-β; PC7; proprotein convertase7; PKC; protein kinase C; ADAM10; A-disintegrin and metalloproteinase 10; TGN; trans-Golgi network; T

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

N-truncation and pyroglutaminylation enhances the opsonizing capacity of Aβ-peptides and facilitates phagocytosis by macrophages and microglia

Keywords: Aβ; amyloid-β; AD; Alzheimer's disease; APP; amyloid precursor protein; BSA; bovine serum albumin; CNS; central nervous system; DAMP; damage-associated molecular pattern; DAPI; 4′,6-diamidino-2-phenylindole; E. coli; Escherichia coli; EDTA; ethylene

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Etazolate, an α-secretase activator, reduces neuroinflammation and offers persistent neuroprotection following traumatic brain injury in mice

Keywords: Traumatic brain injury; sAPPα; Etazolate; Neuroprotection; Neuroinflammation; Functional outcome;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Clinical and neurobiological correlates of soluble amyloid precursor proteins in the cerebrospinal fluid

Keywords: MCI; AD; sAPPα; sAPPβ; CSF;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

ADAM10 expression and promoter haplotype in Alzheimer's disease

Keywords: ADAM10; Haplotype; sAPPα; Alzheimer's disease; Reporter assay; Neuritic plaques; Brain; Hippocampus; Cerebrospinal fluid;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains

Keywords: Amyloid precursor protein; Growth factor like domain; E2 domain; sAPPα; Traumatic brain injury;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Effects of fatty acid unsaturation numbers on membrane fluidity and α-secretase-dependent amyloid precursor protein processing

Keywords: AA; arachidonic acid; AD; Alzheimer's disease; ADAM; a disintegrin and metalloprotease; ALA; α-linolenic acid; APP; amyloid precursor protein; Aβ; amyloid-β peptide; BCA; bicinchoninic acid; BSA; bovine serum albumin; DHA; docosahexaenoic acid; DMEM; D

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

The emergence of designed multiple ligands for neurodegenerative disorders

Keywords: ACh; acetylcholine; A2A; adenosine receptor subtype two-A; Aβ; amyloid-beta; ACE; angiotensin converting enzyme; BDNF; brain derived neurotrophic factor; GDNF; glial derived neurotrophic factors; MAO-B; monoamine oxidase B; AChE; acetylcholinesterase; AP

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Salidroside attenuates hypoxia-induced abnormal processing of amyloid precursor protein by decreasing BACE1 expression in SH-SY5Y cells

Keywords: Aβ; amyloid-beta; AD; Alzheimer's disease; ADAM; a disintegrin and metalloproteinase; APP; amyloid precursor protein; BACE; β-site APP cleaving enzyme; sAPPα; soluble amyloid precursor protein α; HIF-1α; hypoxia-inducible factor 1α; HRE; hypoxia res

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Aβ secretion

Keywords: Aβ; amyloid-β peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; APPNL-H4 cells; H4 cells stably expressing Swedish-type of human APP695; ELISA; enzyme-linked immunosorbent assay; FL; full-length; LDH; lactate dehydrogenase; LDL; low-de

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac

Keywords: ACh; acetylcholine; AD; Alzheimer's disease; ADAM; a disintegrin and metalloprotease; Aβ; amyloid β-peptide; APP; amyloid precursor protein; sAPPα; soluble form of the amyloid precursor protein; FSK; forskolin; GEF; guanine nucleotide exchange factor

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه