کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10767596 1050775 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Aβ secretion
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Aβ secretion
چکیده انگلیسی
Berberine is an isoquinoline alkaloid isolated from Coptidis rhizoma, a major herb widely used in Chinese herbal medicine. Berberine's biological activity includes antidiarrheal, antimicrobial, and anti-inflammatory effects. Recent findings show that berberine prevents neuronal damage due to ischemia or oxidative stress and that it might act as a novel cholesterol-lowering compound. The accumulation of amyloid-β peptide (Aβ) derived from amyloid precursor protein (APP) is a triggering event leading to the pathological cascade of Alzheimer's disease (AD); therefore the inhibition of Aβ production should be a rational therapeutic strategy in the prevention and treatment of AD. Here, we report that berberine reduces Aβ levels by modulating APP processing in human neuroglioma H4 cells stably expressing Swedish-type of APP at the range of berberine concentration without cellular toxicity. Our results indicate that berberine would be a promising candidate for the treatment of AD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 352, Issue 2, 12 January 2007, Pages 498-502
نویسندگان
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