Keywords: دبیرستان; Alzheimer's disease; Secretase; β-secretase (BACE) inhibitors; γ-secretase inhibitors (GSIs); γ-secretase modulators (GSMs);
مقالات ISI دبیرستان (ترجمه نشده)
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Keywords: دبیرستان; Alzheimer disease; Amyloid-β peptide; Membrane protein; Protease; Secretase; Degradation;
Keywords: دبیرستان; biomarker; amyloid precursor protein; Alzheimer's disease; dementia; secretase; early diagnosis
Keywords: دبیرستان; Alzheimer's disease; Amyloid β; Amyloid precursor protein; Secretase;
Profiles of β-Amyloid Peptides and Key Secretases in Brain Autopsy Samples Differ with Sex and APOE ε4 Status: Impact for Risk and Progression of Alzheimer Disease
Keywords: دبیرستان; AD; Alzheimer disease; Aβ; β-amyloid; ADAM10; A disintegrin and metalloproteinase domain-containing protein 10/α-secretase (brain); APP; Amyloid Protein Precursor; APOE ε4; Apolipoprotein, allele epsilon4; BACE1; beta-site amyloid precursor protein cl
The role of the NG2 proteoglycan in OPC and CNS network function
Keywords: دبیرستان; NG2; OPC; Cleavage; Secretase; CTF; ICD; LNS; Neuromodulation; Synapse; Glutamate; LTP; Schizophrenia
Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein
Keywords: دبیرستان; Alzheimer disease; APP; BACE; molecular dynamics; subcellular compartmentalization; membrane trafficking; secretase; amyloid; Neuregulin
Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity
Keywords: دبیرستان; AD; Alzheimer disease; FAD; familial AD; Aβ; amyloid-β peptide; APP; amyloid precursor protein; BACE1; β-site APP cleaving enzyme 1; PDMP; dl-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol; DMAPP; (1S,2R-d-erythro-2-N-myristoylamino)-1-phenyl-1
Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways
Keywords: دبیرستان; Alzheimer; Abeta; Amyloid; Tau; Genetics; Next generation sequencing; PICALM; SORL1; EPHA1; APOE; APP; Vaccine; Secretase; Nicastrin; Presenilin; PSEN1; Neurodegeneration; Dementia;
Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Aβ peptides
Keywords: دبیرستان; N-terminally truncated; Aβ; Alzheimer's disease; Neurons; Astrocytes; Microglia; Intracellular; Extracellular; BACE; Secretase;
Intracellular fragment of NLRR3 (NLRR3-ICD) stimulates ATRA-dependent neuroblastoma differentiation
Keywords: دبیرستان; ATRA; Differentiation; Neuroblastoma; NLRR3; Secretase
A cellular model of amyloid precursor protein processing and amyloid-β peptide production
Keywords: دبیرستان; Alzheimer's; BE(2)-M17; Amyloid-beta; In vitro; Secretase; TNF
PerspectiveLessons from a BACE1 inhibitor trial: Off-site but not off base
Keywords: دبیرستان; Aging; Animal model; Brain disorder; CNS; Dementia; Demyelination; Drug trial; Liver damage; Human studies; Melatonin; Neuronal death; Sialylation; Secretase; Side effects; ROS;
Prion protein expression alters APP cleavage without interaction with BACE-1
Keywords: دبیرستان; Prion; Amyloid; Alzheimer's disease; Secretase; Copper;
Alzheimer culprits: Cellular crossroads and interplay
Keywords: دبیرستان; Alzheimer's disease; Amyloid precursor protein; Amyloidogenic pathway; Secretase; G protein-coupled receptor
Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines
Keywords: دبیرستان; Abeta star 56 kDa; ADAM10; APP; Beta amyloid; Canine; Cingulate; C-terminal fragments of APP; Dog; Insulin degrading enzyme; Neprilysin; Oligomer; Secretase; Temporal;
Triazoles as γ-secretase modulators
Keywords: دبیرستان; Alzheimer; Secretase; GSM; Abeta lowering; Lead optimization
Anatabine lowers Alzheimer's Aβ production in vitro and in vivo
Keywords: دبیرستان; Anatabine; Alzheimer; Amyloid; Inflammation; Secretase;
Decreased expression of GGA3 Protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein
Keywords: دبیرستان; AD; Alzheimer's disease; APP; amyloid precursor protein; BACE; beta-APP Cleaving Enzyme; GGA; Golgi-localized γ-ear containing ADP ribosylation factor-binding protein; HC; healthy control; NC; neurological control; SD; standard deviation; TGN; trans-Golg
BACE: Therapeutic target and potential biomarker for Alzheimer's disease
Keywords: دبیرستان; Alzheimer's disease; Secretase; Protease; Aβ amyloid; Neuregulin
Memantine treatment decreases levels of secreted Alzheimer's amyloid precursor protein (APP) and amyloid beta (Aβ) peptide in the human neuroblastoma cells
Keywords: دبیرستان; Amyloid; Alzheimer's drug; beta-Peptide; Dementia; Neuronal cells; Protein processing; sAPP; Secretase; Tissue culture
Role of amyloid beta in lipid homeostasis
Keywords: دبیرستان; Alzheimer's disease; Lipids; Amyloid beta; Sphingolipid; Secretase; Ganglioside; Cholesterol; Raft; Sphingomyelinase; SMase; 3-Hydroxy-3-methylglutaryl CoA; HMGCR
Stereo-controlled synthesis of novel photoreactive γ-secretase inhibitors
Keywords: دبیرستان; Aspartyl proteases; Alzheimer disease; Photoaffinity labeling; Secretase; Dipeptide isostere
MicroRNA regulation of Alzheimer's Amyloid precursor protein expression
Keywords: دبیرستان; ORF, Open reading frame; qRT-PCR, Quantitative RT-PCR; 3′UTR, 3′ untranslated region.MicroRNA; Non-coding RNA; Amyloid precursor protein; Alzheimer's disease; Gene transcription; Secretase
Function, regulation and therapeutic properties of β-secretase (BACE1)
Keywords: دبیرستان; AD, Alzheimer's disease; ADAM, a disintegrin and metalloprotease; APP, amyloid precursor protein; Aβ, amyloid-β-peptide; BACE1, β-site APP cleaving enzyme 1; NRG1, Neuregulin-1; PS, presenilinAlzheimer's disease; Aβ; APP; BACE1; Neuregulin; Secretase
Structural optimization of a CXCR2-directed antagonist that indirectly inhibits γ-secretase and reduces Aβ
Keywords: دبیرستان; Alzheimer’s disease; Secretase; CXCR2; Amyloid beta
Carbamate-appended N-alkylsulfonamides as inhibitors of γ-secretase
Keywords: دبیرستان; Alzheimer's disease; Secretase; Amyloid-β; Sulfonamides;
Inhibition and Modulation of γ-Secretase for Alzheimer's Disease
Keywords: دبیرستان; Alzheimer's disease; amyloid β-protein; amyloid precursor protein; Notch receptor; secretase; γ-secretase;
Effects of sulindac sulfide on the membrane architecture and the activity of γ-secretase
Keywords: دبیرستان; Alzheimer's disease; Alzheimer's disease-related amyloid precursor protein; Lipid rafts; Membrane microdomains; Non-steroidal anti-inflammatory drugs; Secretase
Homer2 and Homer3 interact with amyloid precursor protein and inhibit Aβ production
Keywords: دبیرستان; Amyloid; Secretase; Alzheimer; Neurodegeneration
Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Aβ secretion
Keywords: دبیرستان; Aβ; amyloid-β peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; APPNL-H4 cells; H4 cells stably expressing Swedish-type of human APP695; ELISA; enzyme-linked immunosorbent assay; FL; full-length; LDH; lactate dehydrogenase; LDL; low-de
Methotrexate decreases PP2A methylation and increases tau phosphorylation in neuron
Keywords: دبیرستان; Alzheimer’s disease; APP; Tau; Okadaic acid; PP2A; BACE; Secretase; Methyltransferase
N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated γ-secretase
Keywords: دبیرستان; Secretase; Alzheimer dementia; Modulator; Aspartic protease
Expression of mDab1 promotes the stability and processing of amyloid precursor protein and this effect is counteracted by X11α
Keywords: دبیرستان; Amyloid precursor protein; mDab1; X11α; Secretase; Alzheimer; Neurodegeneration
Abeta(1–40)-induced secretion of matrix metalloproteinase-9 results in sAPPα release by association with cell surface APP
Keywords: دبیرستان; MMP-9; Amyloid precursor protein; Secretase; Integrin; Alzheimer; Amyloid beta peptide
Endocytosis-independent mechanisms of Delta ligand proteolysis
Keywords: دبیرستان; Delta; Notch; ADAM metalloprotease; Endocytosis; Intramembrane proteolysis; Secretase; Neuroblast; Ganglion mother cellDlcdP1, DlcdP2, DlcdP3, C-terminal derived products of cleaved Drosophila Delta; Dlcd, Delta cytosolic domain containing product; Dlec,
Metabolism of amyloid β peptide and pathogenesis of Alzheimer's disease: Towards presymptomatic diagnosis, prevention and therapy
Keywords: دبیرستان; Aging; Alzheimer's disease (AD); Mild cognitive impairment (MCI); Amyloid β peptide (Aβ); Metabolism; Proteolysis; Neprilysin; Secretase; Vaccination
Method for the determination of the levels of β-amyloid peptide in the CSF sampled from freely moving rats
Keywords: دبیرستان; Alzheimer; Amyloid; Cannula; Cisterna magna; CSF sampling; ELISA; Secretase;
Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (β-secretase)
Keywords: دبیرستان; Alzheimer's disease; Inhibitor; Memapsin 2; Secretase;
Chromosome 21 BACE2 haplotype associates with Alzheimer's disease: A two-stage study
Keywords: دبیرستان; Alzheimer; BACE2; Secretase; Chromosome 21; Amyloid; Neuropathology;
Cholesterol homeostasis failure as a unifying cause of synaptic degeneration
Keywords: دبیرستان; Apolipoprotein E; BACE; Dementia; Immunization; HDL; Lipid; Lipoprotein; Neuron; Phospholipid; Secretase; Synapse;
Regulation of ApoE receptor proteolysis by ligand binding
Keywords: دبیرستان; Disorders of the nervous system; Degenerative disease: Alzheimer's-miscellaneous; apoE; Lipoprotein; Signaling; Cholesterol; Secretase; Alzheimer;
Reductions in β-amyloid concentrations in vivo by the γ-secretase inhibitors BMS-289948 and BMS-299897
Keywords: دبیرستان; Aβ; β-amyloid; APP; Amyloid precursor protein; DAPT; [N-(3,5-difluor-phenacetyl)-l-alanyl]-S-phenylglycine; BMS-289948; 4-chloro-N-(2,5-difluorophenyl)-N-((1R)-{4-fluoro-2-[3-(1H-imidazol-1-yl)propyl]phenyl}ethyl)benzenesulfonamide hydrochloride; BMS-29
Current Concepts in Therapeutic Strategies Targeting Cognitive Decline and Disease Modification in Alzheimer's Disease
Keywords: دبیرستان; Alzheimer's disease; symptomatic; amyloid; immunization; secretase; Aβ;
Inhibition of angiogenesis and tumor growth by β and γ-secretase inhibitors
Keywords: دبیرستان; Tumor growth; Angiogenesis; Secretase; Amyloid precursor protein; Presenilin;