کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5737470 | 1614724 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oleocanthal ameliorates amyloid-β oligomers' toxicity on astrocytes and neuronal cells: In vitro studies
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کلمات کلیدی
PBSsAPPαsAPPβGLUT1RIPAAPPABCA1OleocanthalEVOOACMAβGFAPIL-6BSA - BSADMSO - DMSOGLT1 - GLT-1Astrocytes - آستروسیتbovine serum albumin - آلبومین سرم گاوamyloid-β - آمیلوئید βinsulin-degrading enzyme - آنزیم تحقیر کننده انسولینApoe - آپوapolipoprotein E - آپولیپوپروتئین ENeuroinflammation - التهاب عصبیAβ oligomers - الیگومرهای Aβinterleukin-6 - اینترلوکین ۶IDE - اینجاAlzheimer’s disease - بیماری آلزایمرGlutamate transporter - حمل و نقل گلوتاماتGlucose transporter - حمل و نقل گلوکزAβo - دو تاDimethyl sulfoxide - دیمتیل سولفواکسیدExtra-virgin olive oil - روغن زیتون اضافیBlood–brain barrier - سد خونی مغزیBBB - سد خونی مغزیradioimmunoprecipitation assay - سنجش radioimmunoprecipitationphosphate buffer saline - فسفات بافر شورNeurons - نورون ها،یاخته های عصبیGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایالamyloid precursor protein - پروتئین پیش ماده آمیلوئی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Extra-virgin olive oil (EVOO) has several health promoting effects. Evidence have shown that EVOO attenuates the pathology of amyloid-β (Aβ) and improves cognitive function in experimental animal models, suggesting it's potential to protect and reduce the risk of developing Alzheimer's disease (AD). Available studies have linked this beneficial effect to oleocanthal, one of the active components in EVOO. The effect of oleocanthal against AD pathology has been linked to its ability to attenuate Aβ and tau aggregation in vitro, and enhance Aβ clearance from the brains of wild-type and AD transgenic mice in vivo. However, the ability of oleocanthal to alter the toxic effect of Aβ on brain parenchymal cells is unknown. In the current study, we investigated oleocanthal effect on modulating Aβ oligomers (Aβo) pathological events in neurons and astrocytes. Our findings demonstrated oleocanthal prevented Aβo-induced synaptic proteins, SNAP-25 and PSD-95, down-regulation in neurons, and attenuated Aβo-induced inflammation, glutamine transporter (GLT1) and glucose transporter (GLUT1) down-regulation in astrocytes. Aβo-induced inflammation was characterized by interleukin-6 (IL-6) increase and glial fibrillary acidic protein (GFAP) upregulation that were reduced by oleocanthal. In conclusion, this study provides further evidence to support the protective effect of EVOO-derived phenolic secoiridoid oleocanthal against AD pathology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 352, 3 June 2017, Pages 204-215
Journal: Neuroscience - Volume 352, 3 June 2017, Pages 204-215
نویسندگان
Yazan S. Batarseh, Loqman A. Mohamed, Sweilem B. Al Rihani, Youssef M. Mousa, Abu Bakar Siddique, Khalid A. El Sayed, Amal Kaddoumi,