Keywords: آنزیم تحقیر کننده انسولین; Insulin-degrading enzyme; Hepatic insulin resistance; Insulin receptor; Carcinoembryonic antigen-related cell adhesion molecule 1;
مقالات ISI آنزیم تحقیر کننده انسولین (ترجمه نشده)
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Keywords: آنزیم تحقیر کننده انسولین; 3V; dorsal third ventricle; Ab; amyloid beta; AD; Alzheimer's disease; IDE; insulin-degrading enzyme; IR; insulin receptor; MWM; Morris water maze; pCREB; phospho-cyclic AMP response element-binding protein; STZ; streptozotocin; SST; somatostatin; Dendrit
Keywords: آنزیم تحقیر کننده انسولین; Aβ; amyloid β; AADC; L-amino acid decarboxylase; ACC; Anterior cingulate cortex; AD; Alzheimer's disease; aMCI; Amnestic mild cognitive impairment; APP; Amyloid precursor protein; AR; Adrenergic receptor; ATMX; atomoxetine; BDNF; Brain-derived neurotrop
Keywords: آنزیم تحقیر کننده انسولین; 7,8-DHF; 7,8-dihydroxyflavone; Aβ; amyloid beta; AchE; acetylcholine-esterase; ABCA1; ATP-binding cassette transporter 1; APP; amyloid precursor protein; Akt; protein kinase B; ApoE; apolipoprotein E; AAV/Aβ; adeno-associated viral vector carrying Aβ c
The Protective Effects of IGF-I against β-Amyloid-related Downregulation of Hippocampal Somatostatinergic System Involve Activation of Akt and Protein Kinase A
Keywords: آنزیم تحقیر کننده انسولین; AC; adenylyl cyclase; AD; Alzheimer's disease; Akt; protein kinase B; Aβ; beta-amyloid; BDNF; brain-derived neurotrophic factor; CCK; cholecystokinin, CRE, cyclic AMP response element; CREB; CRE-binding protein; GABA; γ-aminobutyric acid; GFAF; glial
Insulin-signaling Pathway Regulates the Degradation of Amyloid β-protein via Astrocytes
Keywords: آنزیم تحقیر کننده انسولین; ACE; angiotensin-converting enzyme; AD; Alzheimer's disease; AÃ; amyloid Ã-protein; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; ECE; endothelin-converting enzyme; EDTA; ethylenediaminetetraacetic acid; EGCG; epigallocatechi
ReviewAmylin and its G-protein-coupled receptor: A probable pathological process and drug target for Alzheimer's disease
Keywords: آنزیم تحقیر کننده انسولین; AD; Alzheimer's disease; AmR; amylin receptor; Aβ; amyloid-β peptide; BBB; blood-brain barrier; CGRP; calcitonin gene-related peptide; CTR; calcitonin receptor; GPCR; G-protein-coupled receptor; IDE; insulin-degrading enzyme; LRP1; lipoprotein recep
Rebamipide reduces amyloid-β 1-42 (Aβ42) production and ameliorates Aβ43-lowered cell viability in cultured SH-SY5Y human neuroblastoma cells
Keywords: آنزیم تحقیر کننده انسولین; Aβ; amyloid-beta; AD; Alzheimer's disease; ADAM; a disintegrin and metalloproteinase; APP; amyloid precursor protein; ASPD; amylospheroids; BCA; bicinchoninic acid; BACE1; β-site APP-cleaving enzyme-1; BDNF; brain-derived neurotrophic factor; BSA; bov
Oleocanthal ameliorates amyloid-β oligomers' toxicity on astrocytes and neuronal cells: In vitro studies
Keywords: آنزیم تحقیر کننده انسولین; ABCA1; ATP-binding cassette transporter-A1; ACM; astrocyte-conditioned media; AD; Alzheimer's disease; ApoE; apolipoprotein E; APP; amyloid precursor protein; Aβ; amyloid-β; Aβm; Aβ monomer; Aβo; Aβ oligomers; BBB; blood-brain barrier; BSA; bovi
Dexibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways
Keywords: آنزیم تحقیر کننده انسولین; AD; Alzheimer's disease; Aβ; Amyloid beta; APP; Amyloid precursor protein; NFTs; Neurofibrillary tangles; BACE1; β-secretase 1; TNF-α; Tumor necrosis factor; iNOS; Inducible nitric oxide synthase; NSAIDs; Non-steroidal anti-inflammatory drugs; PPARγ;
Decreased IDE and IGF2 expression but increased Aβ40 in the cerebral cortex of mouse pups by early life lead exposure
Keywords: آنزیم تحقیر کننده انسولین; Lead; Cerebral cortex; Insulin-degrading enzyme; Insulin-like growth factor 2; Beta amyloid protein 40; Learning and memory
Characterization of insulin-degrading enzyme-mediated cleavage of Aβ in distinct aggregation states
Keywords: آنزیم تحقیر کننده انسولین; Amyloid-beta; Insulin-degrading enzyme; Neprilysin; Alzheimer's disease; Aggregation; Aβ cleavage;
Methods to monitor monocytes-mediated amyloid-beta uptake and phagocytosis in the context of adjuvanted immunotherapies
Keywords: آنزیم تحقیر کننده انسولین; Aβ; amyloid-beta; AD; Alzheimer's disease; APP; amyloid precursor protein; AS01B; adjuvant system 01B; BSA; bovine serum albumin; DMEM; Dulbecco's modified Eagle medium; DPBS; Dulbecco's Phosphate Buffered Saline; EOAD; early-onset AD; Fig.; figure; FMOs
Peroxisome proliferator activated receptor gamma (PPARγ) as a therapeutic target for improvement of cognitive performance in Fragile-X
Keywords: آنزیم تحقیر کننده انسولین; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; CNS; central nervous system; ECM; extra cellular matrix; FMR1 gene; Fragile X mental retardation 1 gene; FMRP; Fragile-X mental retardation protein; FXS; Fragile X syndrome; GLUT-3; gl
Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum
Keywords: آنزیم تحقیر کننده انسولین; AMPK; AMP-activated protein kinase; STAT; activator of transcription; AGE; advanced glycation end products; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid-β peptide; ACE; angiotensin converting enzyme; Ang I; angiotensin I; AR-II;
An upstream promoter element blocks the reverse transcription of the mouse insulin-degrading enzyme gene
Keywords: آنزیم تحقیر کننده انسولین; Bidirectional promoter; CpG Island; Insulin-degrading enzyme; Unidirectional promoter;
ReviewMolecular links between Alzheimer's disease and diabetes mellitus
Keywords: آنزیم تحقیر کننده انسولین; AD; Alzheimer's disease; APP; amyloid β precursor protein; BACE1; β-site APP-cleaving enzyme 1; Aβ; amyloid β protein; hIAPP; human islet amyloid polypeptide; IDE; insulin-degrading enzyme; IGF; insulin-like growth factor; GSK3β; glycogen synthase
Insulin-degrading enzyme deficiency in bone marrow cells increases atherosclerosis in LDL receptor-deficient mice
Keywords: آنزیم تحقیر کننده انسولین; Atherosclerosis; Insulin-degrading enzyme; LDL receptor-deficient mice; Bone marrow transplantation; Amyloid; Receptor for advanced glycation end products (RAGE)
Insulin-degrading enzyme deficiency accelerates cerebrovascular amyloidosis in an animal model
Keywords: آنزیم تحقیر کننده انسولین; Alzheimer’s disease; Cerebrovascular disease; Insulin-degrading enzyme; Endothelial cells; TGF-β1
Association between variants in IDE-KIF11-HHEX and plasma amyloid β levels
Keywords: آنزیم تحقیر کننده انسولین; Amyloid beta; Alzheimer's disease; Genetics; Insulin-degrading enzyme;
Regular ArticleThe effect of amyloid associated proteins on the expression of genes involved in amyloid-β clearance by adult human astrocytes
Keywords: آنزیم تحقیر کننده انسولین; Astrocytes; Amyloid-β; Clearance; Neprilysin; Insulin-degrading enzyme; MMP-9; SCARB1; MARCO; Megalin; LRP2;
Hepatic Cannabinoid Receptor-1 Mediates Diet-Induced Insulin Resistance via Inhibition of Insulin Signaling and Clearance in Mice
Keywords: آنزیم تحقیر کننده انسولین; NASH; Signal Transduction; Mouse Model, Liver Disease; CB1; cannabinoid receptor-1; ER; endoplasmic reticulum; GTP[γS]; [35S]guanosine 5â²-[γ-thio]triphosphate; HFD; high-fat diet; IDE; insulin-degrading enzyme; JNK; c-Jun NH2-terminal kinase 1; PBA; 4
Retinoblastoma protein co-purifies with proteasomal insulin-degrading enzyme: Implications for cell proliferation control
Keywords: آنزیم تحقیر کننده انسولین; CDKs, cyclin-dependent kinases; RB, retinoblastoma tumor suppressor protein; IDE, insulin-degrading enzyme; FCS, fetal calf serum; PBSCM, PBS containing 1 mM CaCl2 and 1 mM MgCl2Retinoblastoma tumor suppressor protein; Insulin-degrading enzyme; Nucleus; H
Insulin-degrading enzyme antagonizes insulin-dependent tissue growth and Aβ-induced neurotoxicity in Drosophila
Keywords: آنزیم تحقیر کننده انسولین; IDE; insulin-degrading enzyme; DM2; type 2 diabetes mellitus; AD; Alzheimer's disease; LOAD; late-onset AD; GK rat; Goto-Kakizaki rat; dilp2; Drosophila insulin-like peptide 2; InR; insulin receptor; Aβ; β-amyloid; APP; Aβ precursor protein; BACE; β
A highly sensitive peptide substrate for detecting two Aβ-degrading enzymes: Neprilysin and insulin-degrading enzyme
Keywords: آنزیم تحقیر کننده انسولین; Neprilysin; Insulin-degrading enzyme; Aβ; Alzheimer; Amyloid; Digestion; Fluorescence; Quench;
Antagonist of peroxisome proliferator-activated receptor γ induces cerebellar amyloid-β levels and motor dysfunction in APP/PS1 transgenic mice
Keywords: آنزیم تحقیر کننده انسولین; Peroxisome proliferator-activated receptor γ; Amyloid-β; Cerebellum; Cerebellar dysfunction; GW9662; Insulin-degrading enzyme; Alzheimer’s disease
ApoE 4 reduces the expression of Aβ degrading enzyme IDE by activating the NMDA receptor in hippocampal neurons
Keywords: آنزیم تحقیر کننده انسولین; Alzheimer's disease; ApoE4; Insulin-degrading enzyme; NMDA receptor; PKA;
A capillary electrophoresis method for evaluation of Aβ proteolysis in vitro
Keywords: آنزیم تحقیر کننده انسولین; Alzheimer’s disease; Amyloid beta; Insulin-degrading enzyme; Capillary electrophoresis
PPARγ transcriptionally regulates the expression of insulin-degrading enzyme in primary neurons
Keywords: آنزیم تحقیر کننده انسولین; Insulin-degrading enzyme; Peroxisome proliferator-activated receptor γ; Type 2 diabetes mellitus; Alzheimer’s disease; Transcriptional regulation
Reduced neuronal expression of insulin-degrading enzyme in the dorsolateral prefrontal cortex of patients with haloperidol-treated, chronic schizophrenia
Keywords: آنزیم تحقیر کننده انسولین; Schizophrenia; Insulin-degrading enzyme; Neocortex; Hypothalamus; Basal nucleus of Meynert; Morphometry; Western blot; Haloperidol; Neuropeptides
Immunocapture-based fluorometric assay for the measurement of insulin-degrading enzyme activity in brain tissue homogenates
Keywords: آنزیم تحقیر کننده انسولین; Insulin-degrading enzyme; Fluorogenic substrate; Immunocapture; Alzheimer's disease; Insulin-dependent diabetes
Association of polymorphisms in the insulin-degrading enzyme gene with type 2 diabetes in the Korean population
Keywords: آنزیم تحقیر کننده انسولین; Insulin-degrading enzyme; Polymorphism; Type 2 diabetes mellitus
Association of genetic variants of insulin degrading enzyme with metabolic features in women with polycystic ovary syndrome
Keywords: آنزیم تحقیر کننده انسولین; Polycystic ovary syndrome; insulin resistance; single nucleotide polymorphism; insulin-degrading enzyme; gene
Regional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitary
Keywords: آنزیم تحقیر کننده انسولین; Insulin-degrading enzyme; Immunohistochemistry; Human brain; Neurons; Oligodendrocytes; Blood vessels; Pituitary
Regulation of protein degradation by insulin-degrading enzyme: Analysis by small interfering RNA-mediated gene silencing
Keywords: آنزیم تحقیر کننده انسولین; Insulin-degrading enzyme; Protein degradation; siRNA; HepG2 cells
Molecular connexions between dementia and diabetes
Keywords: آنزیم تحقیر کننده انسولین; Diabetes; Alzheimer's disease; Insulin; GSK3; Insulin-degrading enzyme; PhosphorylationT2DM; Type II diabetes mellitus; AD; Alzheimer's disease; MCI; Mild cognitive impairment; NFT; Neurofibrillary tangle; IR; Insulin receptor; PKB; Protein kinase B; GSK3
Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice
Keywords: آنزیم تحقیر کننده انسولین; Glucocorticoids; Insulin-degrading enzyme; Insulin resistance; Metyrapone; Peroxisome proliferator-activated receptor-γ; Stress; Thiazolidinedione
Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis
Keywords: آنزیم تحقیر کننده انسولین; Insulin; Amyloid β-peptide; Insulin-degrading enzyme; Type 2 diabetes and Alzheimer's disease
Insulin-degrading enzyme degrades amyloid peptides associated with British and Danish familial dementia
Keywords: آنزیم تحقیر کننده انسولین; Amyloid; Degradation; Hereditary dementia; Insulin-degrading enzyme; Neurodegeneration; Cerebrovascular amyloidoses;
Age- and region-dependent alterations in Aβ-degrading enzymes: implications for Aβ-induced disorders
Keywords: آنزیم تحقیر کننده انسولین; Amyloid β-protein; Insulin-degrading enzyme; Neprilysin; Aβ; AD; IDE; IBM;
The role of inflammation in Alzheimer's disease
Keywords: آنزیم تحقیر کننده انسولین; αBTx; α-bungarotoxin; Aβ; beta-amyloid protein; ACh; acetylcholine; AChBP; acetylcholine-binding protein; AChR; nicotinic acetylcholine receptor; AD; Alzheimer's disease; AICD; amyloid precursor protein intracellular domain; AP; amyloid P; APP; amyloid