Inhibition of GABA synthesis in the prefrontal cortex increases locomotor activity but does not affect attention in the 5-choice serial reaction time task

► Decreasing cortical GABA synthesis does not affect attention and may reduce motivation. ► Decreasing cortical GABA synthesis increases impulsive behavior and locomotor activity. ► Reduced cortical GABA synthesis may underlie some schizophrenia-like cognitive deficits.