Location is everything: Neurons born during fluoxetine treatment accumulate in regions that do not support spatial learning

► Adult hippocampal neurogenesis is consistently linked to both mood and memory. ► Fluoxetine's effect on memory is disputed, despite up-regulating neurogenesis. ► Knowing the location and function of newborn neurons may resolve this discrepancy. ► Fluoxetine-induced neurons express activity-related genes normally. ► Fluoxetine-induced neurons accumulate largely in areas not engaged by memory tasks.