Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy

► A structure-based drug design yielded a new class of modulator of AMPA receptors. ► JAMI1001A binds in the solvent accessible pocket between AMPA receptor dimers. ► JAMI1001A alters desensitization and deactivation of flip and flop isoforms of GluA2.