Invited reviewLipid rafts, synaptic transmission and plasticity: Impact in age-related neurodegenerative diseases

The synapse is a crowded area. In the last years, the concept that proteins can be organized in different membrane domains according to their structure has emerged. Cholesterol-rich membrane domains, or lipid rafts, form an organized portion of the membrane that is thought to concentrate signaling molecules. Accumulating evidence has shown that both the pre-synaptic and post-synaptic sites are highly enriched in lipid rafts, which are likely to organize and maintain synaptic proteins in their precise localization. Here we review recent studies highlighting the importance of lipid rafts for synaptic function and plasticity, as well as their relevance for age or disease-related cognitive impairment.This article is part of a Special Issue entitled 'Cognitive Enhancers'.

► Cholesterol-rich membrane domains, or lipid rafts, are organized membrane portions. ► Both the pre-synaptic and post-synaptic sites are highly enriched in lipid rafts. ► Lipid rafts concentrate signaling molecules. ► Lipid rafts influence neurotransmission, synaptic plasticity and neurodegeneration. ► Lipid rafts help to organize synaptic proteins with impact upon cognition and ageing.