Modafinil effects on cognition and emotion in schizophrenia and its neurochemical modulation in the brain

► Modafinil has pro-mnemonic effects and improves problem solving in schizophrenia. ► The neural mechanisms of action of modafinil involve key brain regions involved in cognition. ► Modafinil's cognitive enhancing functions are conducted via monoamines, glutamate, GABA, histamine and orexin.