The nicotinic α7 receptor agonist GTS-21 improves cognitive performance in ketamine impaired rhesus monkeys

► Preclinical, translatable models of schizophrenia-specific cognition are needed. ► A ketamine-impaired object retrieval assay was developed in the rhesus monkey. ► GTS-21, but not donepezil, reversed the ketamine-induced cognitive impairment. ► This model could provide vital translation between the clinic and preclinic.