Allosteric alpha-7 nicotinic receptor modulation and P50 sensory gating in schizophrenia: A proof-of-mechanism study

► We tested a novel positive allosteric α7 nicotinic acetylcholine receptor modulator. ► Proof-of-mechanism study measuring event-related potentials in stable schizophrenia. ► Multiple dose scheme. ► Sensitivity analyses included gene variants of the CHRNA7 gene. ► No significant drug effect on sensory P50 gating.