A selective dopamine reuptake inhibitor improves prefrontal cortex-dependent cognitive function: Potential relevance to attention deficit hyperactivity disorder

► AHN 2-005 is a selective dopamine reuptake inhibitor lacking reinforcing effects. ► AHN 2-005 improved prefrontal-dependent cognition. ► AHN 2-005 increased extracellular dopamine and norepinephrine in prefrontal cortex. ► These actions are similar to those produced by ADHD-related drugs.