Serotonergic involvement in the amelioration of behavioral abnormalities in dopamine transporter knockout mice by nicotine

► Nicotine attenuated hyperlocomotion in DAT KO mice. ► Nicotinic effect on hyperlocomotion was reversed by 5-HT1A antagonism. ► PPI deficit in DAT KO mice ameliorated by nicotine treatment. ► 5-HT1A agonist ameliorated PPI deficits in DAT KO mice.