Stimulation of serotonin 2A receptors facilitates consolidation and extinction of fear memory in C57BL/6J mice

► We investigated the role of 5-HT2A receptors in modulation of memory processes in mice. ► The agonist TCB-2 enhanced the consolidation of both fear memory and object memory. ► Fear memory extinction was facilitated by TCB-2 and impaired by the antagonist MDL 11,939. ► MDL 11,939 blocked the TCB-2-induced enhancement of object memory. ► The results provide new insight into the modulation of memory processes by 5-HT.