The neurogenesis hypothesis of affective and anxiety disorders: Are we mistaking the scaffolding for the building?

► Neurons are generated throughout life from stem/progenitor cells in the hippocampus. ► New neurons are suggested to be important for depression pathophysiology/treatment. ► Ablation of neurogenesis is not usually sufficient to induce depression or anxiety. ► Antidepressant-induced neurogenesis is context- and strain-dependent. ► Neurogenesis is required for behavioral responses in specific models of depression.