Evidence for involvement of nitric oxide and GABAB receptors in MK-801- stimulated release of glutamate in rat prefrontal cortex

► MK-801 induces increased extracellular glutamate in prefrontal cortex. ► MK-801-induced glutamate release is attenuated by nitric oxide inhibition. ► Extracellular glutamate in prefrontal cortex is elevated by increased nitric oxide. ► MK-801-induced glutamate release is attenuated by GABAB receptor activation.