Retention of a new-defined intron changes pharmacology and kinetics of the full-length P2X2 receptor found in myenteric neurons of the guinea pig

► We proposed a new arrangement of P2X2 receptor gene with 12 exons and 11 introns. ► Retention of 11th intron in P2X2 receptor changes pharmacology and kinetics. ► Myenteric neurons have three P2X2 receptor variants being P2X2-1 the most common.