Differential effects of NMDA antagonists on high frequency and gamma EEG oscillations in a neurodevelopmental model of schizophrenia

► Treatment with MAM on GD17 models aspects of schizophrenia. ► NMDAR antagonists increase wakefulness, LMA, gamma and high freq oscillations. ► MAM animals have increased response only to the open channel NMDAR blockers. ► Reduced gamma oscillations in MAM animals correlate to reduce PV expression.