کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5825069 1119885 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antidepressant Agents in Short Bowel Syndrome
ترجمه فارسی عنوان
عوامل ضد افسردگی در سندرم کوتاه مدت روده
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی

PurposeThis study aimed to determine whether short small intestine modifies antidepressant concentrations.MethodsThe Css values and concentration-dose ratios (CDRs) of citalopram or escitalopram, administered orally or intravenously, were determined in patients with short bowel syndrome.FindingsEight patients (6 males and 2 females) were included in the study. High CDRs were obtained in orally treated patients with >180 cm of small bowel and in those with >80 cm of small bowel and 50% of colon. Three patients had low Css values, including 1 patient who received intravenous treatment.ImplicationsThe variability of drug absorption and metabolism makes prescribing SSRIs challenging in these patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Therapeutics - Volume 36, Issue 12, 1 December 2014, Pages 2029-2033.e3
نویسندگان
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