|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5825069||1119885||2014||8 صفحه PDF||سفارش دهید||دانلود رایگان|
PurposeThis study aimed to determine whether short small intestine modifies antidepressant concentrations.MethodsThe Css values and concentration-dose ratios (CDRs) of citalopram or escitalopram, administered orally or intravenously, were determined in patients with short bowel syndrome.FindingsEight patients (6 males and 2 females) were included in the study. High CDRs were obtained in orally treated patients with >180 cm of small bowel and in those with >80 cm of small bowel and 50% of colon. Three patients had low Css values, including 1 patient who received intravenous treatment.ImplicationsThe variability of drug absorption and metabolism makes prescribing SSRIs challenging in these patients.
Journal: Clinical Therapeutics - Volume 36, Issue 12, 1 December 2014, Pages 2029-2033.e3