Diverse age-related effects of Bacopa monnieri and donepezil in vitro on cytokine production, antioxidant enzyme activities, and intracellular targets in splenocytes of F344 male rats

► In vitro addition of brahmi to splenocytes of old rats increased cytokine production. ► Brahmi and donepezil enhanced catalase and SOD activity, respectively. ► Brahmi and donepezil increased p-ERK1/2 and p-CREB in splenocytes of old rats. ► Brahmi reversed age-related decline in p-Akt expression in splenocytes.